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Dogs may look to humans for help in solving impossible tasks thanks to some genes previously linked to social disorders in people.

Beagles with particular variants in a gene associated with autism were more likely to sidle up to and make physical contact with a human stranger, researchers report September 29 in Scientific Reports.

That gene, SEZ6L, is one of five genes in a particular stretch of beagle DNA associated with sociability in the dogs, animal behaviorist Per Jensen and colleagues at Linköping University in Sweden say. Versions of four of those five genes have been linked to human social disorders such as autism, schizophrenia and aggression.
“What we figure has been going on here is that there are genetic variants that tend to make dogs more sociable and these variants have been selected during domestication,” Jensen says.

But other researchers say the results are preliminary and need to be confirmed by looking at other dog breeds. Previous genetic studies of dog domestication have not implicated these genes. But, says evolutionary geneticist Bridgett vonHoldt of Princeton University, genes that influence sociability are “not an unlikely target for domestication — as humans, we would be most interested in a protodog that was interested in spending time with humans.”

Most dog studies take DNA samples from pets or village dogs and wild wolves. Jensen’s team instead studied beagles that had been raised in a lab. None of the dogs had been trained. To test sociability, the researchers gave the dogs an unsolvable problem in a room with a female human observer whom the beagles had never seen before. The puzzle was a device with three treats that the dogs could see and smell under sliding lids. One lid was sealed shut and could not be opened.

After opening two lids, the dogs “get very confident that this is not a difficult task, but then they encounter the third lid and that’s where the problem gets impossible,” Jensen says. Wolves would have kept trying to solve the problem on their own (SN: 10/17/15, p. 10). But after some futile attempts, many of the beagles looked to the human observer for help. Some dogs tried to catch her eye, glancing back and forth between the woman and the stuck lid. Other dogs made physical contact with or just tried to stay to close to the woman.

The researchers then looked for places in the dogs’ DNA where the most and least human-friendly dogs differed. A region on chromosome 26 kept popping up, indicating that genes in that region could be involved in social interactions with people.
The finding is a statistical signal, but doesn’t establish what the genes might be doing to influence the dogs’ behavior, says Adam Freedman, an evolutionary geneticist at Harvard University. And since the researchers only examined the beagles, it’s not clear that the same genes would affect behavior in other dogs, he says.

The 2016 Nobel Prize in physics is awarded for discoveries of exotic states of matter known as topological phases that can help explain phenomena such as superconductivity.

The prize is shared among three researchers: David J. Thouless, of the University of Washington in Seattle, F. Duncan M. Haldane of Princeton University and J. Michael Kosterlitz of Brown University. The Royal Swedish Academy of Sciences announced the prize October 4.

At the heart of their work is topology, a branch of mathematics that describes steplike changes in a property. An object can have zero, one or two holes, for example, but not half a hole. This year’s Nobel laureates found that topological effects could explain behaviors seen in superconductors and superfluids. “Like most discoveries, you stumble onto them and you just come to realize there is something really interesting there,” Haldane said in a phone call during the announcement.

Elephants don’t wear high heels, but they certainly walk like they do.

Foot problems plague pachyderms in captivity. But it hasn’t been clear what about captivity drives these problems.

Olga Panagiotopoulou of the University of Queensland in Australia and colleagues tested walking in nearly wild elephants. The team trained five free-ranging elephants at a park in South Africa to walk over pressure-sensing platforms to map the distribution of weight on their feet. The team compared the data with similar tests of Asian elephants in a zoo in England.

Regardless of species or setting, a trend emerged: Elephants put the most pressure on the outside toes of their front feet and the least pressure on their heels, the team reports October 5 in Royal Society Open Science. Thus, elephants naturally walk on their tiptoes. The harder surfaces of captive environments must cramp a natural walking style, the researchers conclude.

Accidental chair squeaks in a lab have tipped off researchers to a new world of eavesdroppers.

Spiders don’t have eardrums, though their exquisitely sensitive leg hairs pick up vibrations humming through solids like web silk and leaves. Biologists thought that any airborne sounds more than a few centimeters away would be inaudible. But the first recordings of auditory nerve cells firing inside a spider brain suggest that the tiny Phidippus audax jumping spider can pick up airborne sounds from at least three meters away, says Ronald Hoy of Cornell University.
During early sessions of brain recordings, Hoy’s colleagues saw bursts of nerve cell, or neuron, activity when a chair moved. Systematic experiments then showed that from several meters away, spiders were able to detect relatively quiet tones at levels comparable to human conversation. In a hearing test based on behavior, the spiders also clearly noticed when researchers broadcast a low droning like the wing sound of an approaching predatory wasp. In an instant, the spiders hunkered down motionless, the researchers report online October 13 in Current Biology.

Jumping spiders have brains about the size of a poppy seed, and Hoy credits the success of probing even tinier spots inside these (anesthetized) brains to Cornell coauthor Gil Menda and his rock-steady hands. “I close my eyes,” Menda says. He listens his way along, one slight nudge of the probe at a time toward the auditory regions, as the probe monitor’s faint popping sounds grow louder.
When Menda first realized the spider brain reacted to a chair squeak, he and Paul Shamble, a study coauthor now at Harvard University, started clapping hands, backing away from the spider and clapping again. The claps didn’t seem earthshaking, but the spider’s brain registered clapping even when they had backed out into the hallway, laughing with surprise.
Clapping or other test sounds in theory might confound the experiment by sending vibrations not just through the air but through equipment holding the spider. So the researchers did their Cornell neuron observations on a table protected from vibrations. They even took the setup for the scary wasp trials on a trip to the lab of coauthor Ronald Miles at State University of New York at Binghamton. There, they could conduct vibration testing in a highly controlled, echo-dampened chamber. Soundwise, Hoy says, “it’s really eerie.”

Neuron tests in the hushed chamber and at Cornell revealed a relatively narrow, low-pitched range of sensitivity for these spiders, Hoy says. That lets the spiders pick up rumbly tones pitched around 70 to 200 hertz; in comparison, he says, people hear best between 500 and 1,000 Hz and can detect tones from 50 Hz to 15 kilohertz.
Spiders may hear low rumbles much as they do web vibes: with specialized leg hairs, Hoy and his colleagues propose. They found that making a hair twitch could cause a sound-responsive neuron to fire.
“There seems to be no physical reason why a hair could not listen,” says Jérôme Casas of the University of Tours in France. When monitoring nerve response from hairs on cricket legs, he’s tracked airplanes flying overhead. Hoy’s team calculates that an 80 Hz tone the spiders responded to would cause air velocities of only 0.13 millimeters a second if broadcast at 65 decibels three meters away. That’s hardly a sigh of a breeze. Yet it’s above the threshold for leg hair response, says Friedrich Barth of the University of Vienna, who studies spider senses.

An evolutionary pressure favoring such sensitivity might have been eons of attacks from wasps, such as those that carry off jumping spiders and immobilize them with venom, Hoy says. A mother wasp then tucks an inert, still-alive spider into each cell of her nest where a wasp egg will eventually hatch to feed on fresh spider flesh. Wasps are major predators of many kinds of spiders, says Ximena Nelson of the University of Canterbury in Christchurch, New Zealand. If detecting their wing drone turns out to have been important in the evolution of hearing, other spiders might do long-distance eavesdropping, too.

VANCOUVER — Zika virus’s tricks for interfering with human brain cell development may also be the virus’s undoing.

Zika infection interferes with DNA replication and repair machinery and also prevents production of some proteins needed for proper brain growth, geneticist Feiran Zhang of Emory University in Atlanta reported October 19 at the annual meeting of the American Society of Human Genetics.

Levels of a protein called p53, which helps control cell growth and death, shot up by 80 percent in human brain cells infected with the Asian Zika virus strain responsible for the Zika epidemic in the Americas, Zhang said. The lab dish results are also reported in the Oct. 14 Nucleic Acids Research. Increased levels of the protein stop developing brain cells from growing and may cause the cells to commit suicide.
A drug that inactivates p53 stopped brain cells from dying, Zhang said. Such p53 inhibitors could help protect developing brains in babies infected with Zika. But researchers would need to be careful giving such drugs because too little p53 can lead to cancer.

Zika also makes small RNA molecules that interfere with production of proteins needed for DNA replication, cell growth and brain development, Zhang said. In particular, a small viral RNA called vsRNA-21 reduced the amount of microcephalin 1 protein made in human brain cells in lab dishes. The researchers confirmed the results in mouse experiments. That protein is needed for brain growth; not enough leads to the small heads seen in babies with microcephaly. Inhibitors of the viral RNAs might also be used in therapies, Zhang suggested.

Rocky Mountain hikers might need to start packing more bear spray: Climate change may reduce the time that grizzly bears spend in hibernation — leaving them more time to scare the crap out of any humans wandering in their territory.

Scientists aren’t really concerned about bear hibernation because of unwary hikers, of course. It’s because hibernation is an important time of year for a grizzly bear. By going into hibernation and suppressing their metabolisms, the bears can reduce the amount of energy they expend by some 85 percent and more easily get through months when food supplies are short and weather is bleak. Plus, this is when pregnant females give birth and start raising their young. Disrupt hibernation time and a bear is set for a bad — and potentially deadly — year.

And then there’s the fact that in some places, grizzly bears aren’t doing so well. That’s true in Alberta, Canada, where the bears, already low in number, have been threatened by habitat loss and human hunters and have low reproductive rates.

Karine Pigeon of Laval University in Quebec City and colleagues wanted to know whether they should add climate change to that list of threats. But first they needed more information about the factors that drive the bears into and out of their dens. The bears don’t go into or leave hibernation on specific dates (apparently they don’t use our calendar system), so how do they know when it’s time to hibernate?

To find out, the team captured 15 male and 58 female grizzly bears from 1999 to 2011 in an area along the Alberta-British Columbia border northwest of Calgary. The bears were weighed and measured and fitted with tracking collars. Because the signals from the collars couldn’t be tracked from inside the bears’ dens, the researchers knew when the animals entered and left hibernation. The scientists also collected information about the local weather and the availability of berries, one of the bears’ preferred foods.

No single factor explained the dates on which the grizzlies entered and left hibernation, but some were more important than others, the team reports in the October Behavioral Ecology and Sociobiology. Pregnant females, for instance, entered their dens on average two weeks earlier than males, and the ones that had given birth and had cubs emerged two weeks later. This matched what scientists know about bear denning habits, which are thought to promote the cubs’ safety and development.

The end of hibernation tended to be linked to weather and elevation. A bear denning at high elevation in a year in which spring arrived late would stay snug and warm in its den for longer than a grizzly lower down and when spring arrived early.
The den entry date, though, wasn’t tied to weather. It was partially linked to the availability of food: When there were plenty of tasty berries available, grizzlies tended to stay out and keep eating.

And this is where there’s a problem regarding climate change, the researchers note. Because if longer autumns promote the plentiful production of berries, and earlier springs are bringing milder conditions that prompt bears to leave their dens, then grizzlies may hibernate less. That could have repercussions for females with cubs, the researchers note, because it may lead to smaller, more vulnerable cubs being led out into the open — where humans or other bears could kill them.

Most people do not marvel much at sand. We may enjoy how it feels under our bare feet, or get annoyed when someone tracks it into the house. But few of us see those quartz grains the way geologist Walter Alvarez does — as the product of 4.5 billion years of improbable cosmic and geologic events that defined the course of human history.

Sandy beaches exist because silicon — a relatively rare element in the solar system — happened to become concentrated on Earth during the solar system’s early days, Alvarez, of the University of California, Berkeley, writes in A Most Improbable Journey. While powerful solar particles swept lighter, gaseous elements toward the outer planets, more massive, mineral-forming elements such as silicon, magnesium and iron were left behind for Earth. Later on, in the molten crucibles between Earth’s colliding tectonic plates, these elements formed the raw materials for pivotal human inventions, including stone tools, glass and computer chips.
The 4.5 billion years of history that led to a computer chip is just one of many stories of scientific happenstance that Alvarez presents. Best known for proposing that an asteroid impact killed off the dinosaurs, Alvarez argues that rare, unpredictable cosmic, geologic and biological events — what he calls “contingencies” — are key to understanding the human condition.

Fans of Bill Bryson’s A Short History of Nearly Everything will appreciate Alvarez’s enthusiastic, clearly written tour of contingencies that have shaped our world, starting with the origins of life on Earth. No matter how distant the event, Alvarez quickly zeroes in on its eventual impact on people: For instance, the formation of oceanic crust helped expose rich deposits of copper ore on Cyprus, later an epicenter of the Bronze Age. A catastrophic Ice Age flood formed the English Channel in which the Spanish Armada would later sink. And ancient rivers in North America smoothed the terrain of the westward trail for American pioneers in covered wagons.

Not all of Alvarez’s arguments are convincing — his claim in the final chapter that every individual is a “contingency” in his or her own right, given how many other people could have been born instead, feels more flattering than important. Still, it’s hard to argue with his observation that impulsive human actions can transform the planet just as much as earthquakes, asteroids and other difficult-to-predict, occasionally world-changing phenomena.

Critics of this macro view, described in academia as “Big History,” say that the approach sacrifices important nuance and detail. At roughly 200 pages of text, however, A Most Improbable Journey does not claim to be a comprehensive account of history or a replacement for more detailed, focused examinations of the past. Instead, it makes a compelling case for Big History as a fun, perspective-stretching exercise — a way to dust off familiar topics and make them sparkle.

Muons, electrons’ heftier cousins, rain down through the Earth’s atmosphere in numbers higher than physicists expect. The discrepancy could simply point to a gap in physicists’ understanding of the nitty-gritty physics of particle interactions, or perhaps something unexpected is going on, such as the creation of a new state of matter.

When cosmic rays — spacefaring protons or atomic nuclei — smash into the atmosphere at ultrahigh energies, they launch a cascade of many other types of particles, including muons. New observations made at the Pierre Auger Observatory detect about 30 percent more muons than simulations predict, scientists report October 31 in Physical Review Letters.
The Auger observatory, located in Argentina, uses telescopes to observe faint light from particle showers in the atmosphere, and detects particles that reach the ground using tanks of water. By comparing simulated particle showers to real data, and allowing for possible miscalibration of their detectors, the scientists concluded that the predicted numbers of muons don’t match up with reality. Hints of the muon excess have been popping up since the ’90s, says physicist Thomas Gaisser of the University of Delaware. But the new measurement is “a better job, which confirms the excess compared to what’s predicted by the models.”

The ultrahigh energy cosmic rays that the researchers analyzed probe physics at energies 10 times those reached at the world’s most powerful particle accelerator, the Large Hadron Collider, potentially allowing scientists to detect new phenomena. But, says Spencer Klein of the Lawrence Berkeley National Laboratory in California, “it’s premature to say that this is something really interesting.” He suggests that the discrepancy could simply be due to an incomplete grasp of the physics of how protons and neutrons inside a nucleus behave when nuclei collide. The complexities of that behavior could result in particles that eventually decay into more muons than scientists naïvely expected, thus explaining the glut.

But, says Auger physicist Glennys Farrar of New York University, scientists have unsuccessfully tried to explain the muon surplus using standard physics for many years. “That’s in a way the most convincing reason to think that there may be new physics.” An explanation Farrar favors is a phenomenon in which a new state of matter appears at high energies. In such a state, large numbers of gluons — particles that transmit the strong nuclear force — may behave collectively, like photons in sync in a laser. If enough energy is pumped in by the cosmic rays, the gluons could “start to develop a life of their own,” Farrar says. The gluons might then gang up into hypothetical particles called glueballs, which could decay into particles that produce more muons.

Editor’s Note: After this article was published, Horbatsch and colleagues discovered an error in their analysis, which weakened the conclusions. The new calculation of the proton radius falls in between the two previous estimates, and therefore does not add much additional support for the smaller proton.

A spat over the size of the proton just got a bit more complicated.

Measurements of the proton’s radius disagree, with one group of scientists saying it’s smaller than the accepted estimate. Now, a new analysis of old data bolsters the case for a small proton. But the result may dash hopes that the discrepancy could point the way to new physics.
Scientists at York University in Toronto and the Autonomous University of Barcelona reanalyzed data from a 2010 electron scattering experiment at the Mainz Microtron in Germany, in which physicists bombarded protons with electrons and observed how the electrons ricocheted. That scattering, under the influence of the protons’ spheres of positive charge, allows scientists to tease out the size of a proton. The updated estimate came up small, the scientists report November 1 on arXiv.org.

“I think it’s not going to be easy for the proponents of a relatively large proton radius to just discuss this away,” says physicist Randolf Pohl of the Max Planck Institute of Quantum Optics in Garching, Germany. “But I’m not convinced that people will accept it.”

Until several years ago, scientists’ various techniques for sizing up the proton were in agreement. Electron scattering studies like the Mainz experiment implied the same size proton as a second technique, which involves studying the energy levels of hydrogen atoms. These estimates indicated that the proton’s radius was about 0.88 quadrillionths of a meter. But in 2010, a new technique caused a kerfuffle. Measurements of the proton radius using muonic hydrogen — a hydrogen atom with its electron replaced by a heavier relative called a muon — pegged the proton to a size 4 percent smaller than the other estimates (SN: 7/31/10, p. 7).

The flaw among the three techniques might seem likely to lie with the one outlier, the muon experiment. But “there’s actually quite a bit of certainty about those results,” says physicist Marko Horbatsch of York University, a coauthor of the new paper. So Horbatsch and colleagues decided to revisit electron scattering instead, using a subset of the data from the Mainz experiment. Horbatsch’s team focused on glancing collisions where the electron altered its course only slightly. Those collisions are the most essential for determining the proton radius. Then the researchers used theoretical calculations to account for effects that occur in more extreme collisions. Their analysis revealed a slightly scaled-down proton.

If the result is reinforced by future electron scattering measurements, the hydrogen atom data that resulted in the larger-sized proton would still require explanation. But it would also mean that the discrepancy won’t lead to new insights about the universe. Under the standard model of particle physics, muons and electrons should be identical except for mass. Physicists had hoped that the black sheep status of the muonic hydrogen experiment indicated something was different about muons. Agreement of the electron scattering and muonic hydrogen experiments eliminates that possible explanation.
The new analysis is “undoubtedly sensible,” says physicist Judith McGovern of the University of Manchester. “I’m a bit surprised no one has done it before. In fact, I’m a bit surprised I haven’t done it before.”

But that doesn’t mean scientists are fully convinced. MIT physicist Jan Bernauer, one of the authors of the original electron scattering result, says he doesn’t think the puzzle will be solved by reanalysis of existing data. “I’m positive that new data are needed.”

A hunter’s gaze betrays its strategy. And looking at what an animal looks at when it’s hunting for prey has revealed foraging patterns in humans, other primates — and now, birds.

Suzanne Amador Kane of Haverford College in Pennsylvania and her colleagues watched archival footage of three raptor species hunting: northern goshawks (Accipiter gentilis), Cooper’s hawks (A. cooperii) and red-tailed hawks (Buteo jamaicensis). They also mounted a video camera to the head of a goshawk to record the bird’s perspective (a technique that’s proved useful in previous studies of attack behavior). The team noted how long birds spent fixating on specific points before giving up, moving their head and, thus, shifting their gaze.

When searching for prey, raptors don’t turn their heads in a predictable pattern. Instead, they appear to scan and fixate randomly based on what they see in their environment, Kane and her colleagues report November 16 in The Auk. In primates, a buildup of sensory information drives foraging animals to move their eyes in similar patterns.

Though the new study only examines three species and focuses on head tracking rather than eye tracking, Kane and her colleagues suggest that the same basic neural processes may drive search decisions of human and hawk hunters.