The ghost catfish transforms from glassy to glam when white light passes through its mostly transparent body. Now, scientists know why.
The fish’s iridescence comes from light bending as it travels through microscopic striped structures in the animal’s muscles, researchers report March 13 in the Proceedings of the National Academy of Sciences.
Many fishes with iridescent flair have tiny crystals in their skin or scales that reflect light (SN: 4/6/21). But the ghost catfish (Kryptopterus vitreolus) and other transparent aquatic species, like eel larvae and icefishes, lack such structures to explain their luster.
The ghost catfish’s see-through body caught the eye of physicist Qibin Zhao when he was in an aquarium store. The roughly 5-centimeter-long freshwater fish is a popular ornamental species. “I was standing in front of the tank and staring at the fish,” says Zhao, of Shanghai Jiao Tong University. “And then I saw the iridescence.”
To investigate the fish’s colorful properties, Zhao and colleagues first examined the fish under different lighting conditions. The researchers determined its iridescence arose from light passing through the fish rather than reflecting off it. By using a white light laser to illuminate the animal’s muscles and skin separately, the team found that the muscles generated the multicolored sheen. The researchers then characterized the muscles’ properties by analyzing how X-rays scatter when traveling through the tissue and by looking at it with an electron microscope. The team identified sarcomeres — regularly spaced, banded structures, each roughly 2 micrometers long, that run along the length of muscle fibers — as the source of the iridescence.
The sarcomeres’ repeating bands, comprised of proteins that overlap by varying amounts, bend white light in a way that separates and enhances its different wavelengths. The collective diffraction of light produces an array of colors. When the fish contracts and relaxes its muscles to swim, the sarcomeres slightly change in length, causing a shifting rainbow effect. The purpose of the ghost catfish’s iridescence is a little unclear, says Heok Hee Ng, an independent ichthyologist in Singapore who was not involved in the new study. Ghost catfish live in murky water and seldom rely on sight, he says. But the iridescence might help them visually coordinate movements when traveling in schools, or it could help them blend in with shimmering water to hide from land predators, like some birds, he adds.
Regardless of function, Ng is excited to see scientists exploring the ghost catfish’s unusual characteristics.
“Fishes actually have quite a number of these interesting structures that serve them in many ways,” he says. “And a lot of these structures are very poorly studied.”
Tiny particles of plastic have been found everywhere — from the deepest place on the planet, the Mariana Trench, to the top of Mount Everest. And now more and more studies are finding that microplastics, defined as plastic pieces less than 5 millimeters across, are also in our bodies.
“What we are looking at is the biggest oil spill ever,” says Maria Westerbos, founder of the Plastic Soup Foundation, an Amsterdam-based nonprofit advocacy organization that works to reduce plastic pollution around the world. Nearly all plastics are made from fossil fuel sources. And microplastics are “everywhere,” she adds, “even in our bodies.” In recent years, microplastics have been documented in all parts of the human lung, in maternal and fetal placental tissues, in human breast milk and in human blood. Microplastics scientist Heather Leslie, formerly of Vrije Universiteit Amsterdam, and colleagues found microplastics in blood samples from 17 of 22 healthy adult volunteers in the Netherlands. The finding, published last year in Environment International, confirms what many scientists have long suspected: These tiny bits can get absorbed into the human bloodstream.
“We went from expecting plastic particles to be absorbable and present in the human bloodstream to knowing that they are,” Leslie says. The findings aren’t entirely surprising; plastics are all around us. Durable, versatile and cheap to manufacture, they are in our clothes, cosmetics, electronics, tires, packaging and so many more items of daily use. And the types of plastic materials on the market continues to increase. “There were around 3,000 [plastic materials] when I started researching microplastics over a decade ago,” Leslie says. “Now there are over 9,600. That’s a huge number, each with its own chemical makeup and potential toxicity.”
Though durable, plastics do degrade, by weathering from water, wind, sunlight or heat — as in ocean environments or in landfills — or by friction, in the case of car tires, which releases plastic particles along roadways during motion and braking.
In addition to studying microplastic particles, researchers are also trying to get a handle on nanoplastics, particles which are less than 1 micrometer in length. “The large plastic objects in the environment will break down into micro- and nanoplastics, constantly raising particle numbers,” says toxicologist Dick Vethaak of the Institute for Risk Assessment Sciences at Utrecht University in the Netherlands, who collaborated with Leslie on the study finding microplastics in human blood.
Nearly two decades ago, marine biologists began drawing attention to the accumulation of microplastics in the ocean and their potential to interfere with organism and ecosystem health (SN: 2/20/16, p. 20). But only in recent years have scientists started focusing on microplastics in people’s food and drinking water — as well as in indoor air.
Plastic particles are also intentionally added to cosmetics like lipstick, lip gloss and eye makeup to improve their feel and finish, and to personal care products, such as face scrubs, toothpastes and shower gels, for the cleansing and exfoliating properties. When washed off, these microplastics enter the sewage system. They can end up in the sewage sludge from wastewater treatment plants, which is used to fertilize agricultural lands, or even in treated water released into waterways.
What if any damage microplastics may do when they get into our bodies is not clear, but a growing community of researchers investigating these questions thinks there is reason for concern. Inhaled particles might irritate and damage the lungs, akin to the damage caused by other particulate matter. And although the composition of plastic particles varies, some contain chemicals that are known to interfere with the body’s hormones.
Currently there are huge knowledge gaps in our understanding of how these particles are processed by the human body.
How do microplastics get into our bodies? Research points to two main entry routes into the human body: We swallow them and we breathe them in.
Evidence is growing that our food and water is contaminated with microplastics. A study in Italy, reported in 2020, found microplastics in everyday fruits and vegetables. Wheat and lettuce plants have been observed taking up microplastic particles in the lab; uptake from soil containing the particles is probably how they get into our produce in the first place.
Sewage sludge can contain microplastics not only from personal care products, but also from washing machines. One study looking at sludge from a wastewater treatment plant in southwest England found that if all the treated sludge produced there were used to fertilize soils, a volume of microplastic particles equivalent to what is found in more than 20,000 plastic credit cards could potentially be released into the environment each month.
On top of that, fertilizers are coated with plastic for controlled release, plastic mulch film is used as a protective layer for crops and water containing microplastics is used for irrigation, says Sophie Vonk, a researcher at the Plastic Soup Foundation.
“Agricultural fields in Europe and North America are estimated to receive far higher quantities of microplastics than global oceans,” Vonk says. A recent pilot study commissioned by the Plastic Soup Foundation found microplastics in all blood samples collected from pigs and cows on Dutch farms, showing livestock are capable of absorbing some of the plastic particles from their feed, water or air. Of the beef and pork samples collected from farms and supermarkets as part of the same study, 75 percent showed the presence of microplastics. Multiple studies document that microplastic particles are also in fish muscle, not just the gut, and so are likely to be consumed when people eat seafood.
Microplastics are in our drinking water, whether it’s from the tap or bottled. The particles may enter the water at the source, during treatment and distribution, or, in the case of bottled water, from its packaging.
Results from studies attempting to quantify levels of human ingestion vary dramatically, but they suggest people might be consuming on the order of tens of thousands of microplastic particles per person per year. These estimates may change as more data come in, and they will likely vary depending on people’s diets and where they live. Plus, it is not yet clear how these particles are absorbed, distributed, metabolized and excreted by the human body, and if not excreted immediately, how long they might stick around.
Babies might face particularly high exposures. A small study of six infants and 10 adults found that the infants had more microplastic particles in their feces than the adults did. Research suggests microplastics can enter the fetus via the placenta, and babies could also ingest the particles via breast milk. The use of plastic feeding bottles and teething toys adds to children’s microplastics exposure.
Microplastic particles are also floating in the air. Research conducted in Paris to document microplastic levels in indoor air found concentrations ranging from three to 15 particles per cubic meter of air. Outdoor concentrations were much lower.
Airborne particles may turn out to be more of a concern than those in food. One study reported in 2018 compared the amount of microplastics present within mussels harvested off Scotland’s coasts with the amount of microplastics present in indoor air. Exposure to microplastic fibers from the air during the meal was far higher than the risk of ingesting microplastics from the mussels themselves.
Extrapolating from this research, immunologist Nienke Vrisekoop of the University Medical Center Utrecht says, “If I keep a piece of fish on the table for an hour, it has probably gathered more microplastics from the ambient air than it has from the ocean.” What’s more, a study of human lung tissue reported last year offers solid evidence that we are breathing in plastic particles. Microplastics showed up in 11 of 13 samples, including those from the upper, middle and lower lobes, researchers in England reported.
Perhaps good news: Microplastics seem unable to penetrate the skin. “The epidermis holds off quite a lot of stuff from the outside world, including [nano]particles,” Leslie says. “Particles can go deep into your skin, but so far we haven’t observed them passing the barrier, unless the skin is damaged.”
What do we know about the potential health risks? Studies in mice suggest microplastics are not benign. Research in these test animals shows that lab exposure to microplastics can disrupt the gut microbiome, lead to inflammation, lower sperm quality and testosterone levels, and negatively affect learning and memory.
But some of these studies used concentrations that may not be relevant to real-world scenarios. Studies on the health effects of exposure in humans are just getting under way, so it could be years before scientists understand the actual impact in people.
Immunologist Barbro Melgert of the University of Groningen in the Netherlands has studied the effects of nylon microfibers on human tissue grown to resemble lungs. Exposure to nylon fibers reduced both the number and size of airways that formed in these tissues by 67 percent and 50 percent, respectively. “We found that the cause was not the microfibers themselves but rather the chemicals released from them,” Melgert says.
“Microplastics could be considered a form of air pollution,” she says. “We know air pollution particles tend to induce stress in our lungs, and it will probably be the same for microplastics.”
Vrisekoop is studying how the human immune system responds to microplastics. Her unpublished lab experiments suggest immune cells don’t recognize microplastic particles unless they have blood proteins, viruses, bacteria or other contaminants attached. But it is likely that such bits will attach to microplastic particles out in the environment and inside the body.
“If the microplastics are not clean … the immune cells [engulf] the particle and die faster because of it,” Vrisekoop says. “More immune cells then rush in.” This marks the start of an immune response to the particle, which could potentially trigger a strong inflammatory reaction or possibly aggravate existing inflammatory diseases of the lungs or gastrointestinal tract. Some of the chemicals added to make plastic suitable for particular uses are also known to cause problems for humans: Bisphenol A, or BPA, is used to harden plastic and is a known endocrine disruptor that has been linked to developmental effects in children and problems with reproductive systems and metabolism in adults (SN: 7/18/09, p. 5). Phthalates, used to make plastic soft and flexible, are associated with adverse effects on fetal development and reproductive problems in adults along with insulin resistance and obesity. And flame retardants that make electronics less flammable are associated with endocrine, reproductive and behavioral effects.
“Some of these chemical products that I worked on in the past [like the polybrominated diphenyl ethers used as flame retardants] have been phased out or are prohibited to use in new products now [in the European Union and the United States] because of their neurotoxic or disrupting effects,” Leslie says. Concerning chemicals Bits of plastic floating in the world’s air and water contain chemicals that may pose risks to human health. A 2021 study identified more than 2,400 chemicals of potential concern found in plastics or used in their processing. Here are a few of the most worrisome.
Short-chain chlorinated paraffins are used as lubricants, flame retardants and plasticizers. They can cause cancer in lab rodents, but the mechanisms may not be relevant for human health. The chlorinated compound mirex was once used as a flame retardant and can persist in the environment. It’s suspected of being a human carcinogen and may affect fertility. 2,4,6-Tri-tert-butylphenol is an antioxidant and ultraviolet stabilizer, added to plastics to prevent degradation. There’s evidence that it causes liver damage in lab animals with prolonged or repeated exposure. Benzo(a)pyrene is a polyaromatic hydrocarbon that can be released when organic matter such as coal or wood burns. It is also produced in grilled meats. It has been shown to cause cancer, damage fertility and affect development in lab animals. Dibutyl phthalate is a plasticizer that is known to cause endocrine disruption, may interfere with male fertility and has been shown to affect fetal development in lab animals. Tetrabromobisphenol-A is a flame retardant that can cause cancer in lab animals and may be an endocrine disruptor. It is chemically related to bisphenol A, which has been linked to developmental effects in children. SOURCE: H. WIESINGER, Z. WANG AND S. HELLWEG/ENVIRONMENTAL SCIENCE & TECHNOLOGY 2021 What are the open questions? The first step in determining the risk of microplastics to human health is to better understand and quantify human exposure. Polyrisk — one of five large-scale research projects under CUSP, a multidisciplinary group of researchers and experts from 75 organizations across 21 European countries studying micro- and nanoplastics — is doing exactly that.
Immunotoxicologist Raymond Pieters, of the Institute for Risk Assessment Sciences at Utrecht University and coordinator of Polyrisk, and colleagues are studying people’s inhalation exposure in a number of real-life scenarios: near a traffic light, for example, where cars are likely to be braking, versus a highway, where vehicles are continuously moving. Other scenarios under study include an indoor sports stadium, as well as occupational scenarios like the textile and rubber industry.
Melgert wants to know how much microplastic is in our houses, what the particle sizes are and how much we breathe in. “There are very few studies looking at indoor levels [of microplastics],” she says. “We all have stuff in our houses — carpets, insulation made of plastic materials, curtains, clothes — that all give off fibers.”
Vethaak, who co-coordinates MOMENTUM, a consortium of 27 research and industry partners from the Netherlands and seven other countries studying microplastics’ potential effects on human health, is quick to point out that “any measurement of the degree of exposure to plastic particles is likely an underestimation.” In addition to research on the impact of microplastics, the group is also looking at nanoplastics. Studying and analyzing these smallest of plastics in the environment and in our bodies is extremely challenging. “The analytical tools and techniques required for this are still being developed,” Vethaak says.
Vethaak also wants to understand whether microplastic particles coated with bacteria and viruses found in the environment could spread these pathogens and increase infection rates in people. Studies have suggested that microplastics in the ocean can serve as safe havens for germs.
Alongside knowing people’s level of exposure to microplastics, the second big question scientists want to understand is what if any level of real-world exposure is harmful. “This work is confounded by the multitude of different plastic particle types, given their variations in size, shape and chemical composition, which can affect uptake and toxicity,” Leslie says. “In the case of microplastics, it will take several more years to determine what the threshold dose for toxicity is.”
Several countries have banned the use of microbeads in specific categories of products, including rinse-off cosmetics and toothpastes. But there are no regulations or policies anywhere in the world that address the release or concentrations of other microplastics — and there are very few consistent monitoring efforts. California has recently taken a step toward monitoring by approving the world’s first requirements for testing microplastics in drinking water sources. The testing will happen over the next several years.
Pieters is very pragmatic in his outlook: “We know ‘a’ and ‘b,’” he says. “So we can expect ‘c,’ and ‘c’ would [imply] a risk for human health.”
He is inclined to find ways to protect people now even if there is limited or uncertain scientific knowledge. “Why not take a stand for the precautionary principle?” he asks.
For people who want to follow Pieters’ lead, there are ways to reduce exposure.
“Ventilate, ventilate, ventilate,” Melgert says. She recommends not only proper ventilation, including opening your windows at home, but also regular vacuum cleaning and air purification. That can remove dust, which often contains microplastics, from surfaces and the air.
Consumers can also choose to avoid cosmetics and personal care products containing microbeads. Buying clothes made from natural fabrics like cotton, linen and hemp, instead of from synthetic materials like acrylic and polyester, helps reduce the shedding of microplastics during wear and during the washing process.
Specialized microplastics-removal devices, including laundry balls, laundry bags and filters that attach to washing machines, are designed to reduce the number of microfibers making it into waterways.
Vethaak recommends not heating plastic containers in the microwave, even if they claim to be food grade, and not leaving plastic water bottles in the sun.
Perhaps the biggest thing people can do is rely on plastics less. Reducing overall consumption will reduce plastic pollution, and so reduce microplastics sloughing into the air and water.
Leslie recommends functional substitution: “Before you purchase something, think if you really need it, and if it needs to be plastic.”
Westerbos remains hopeful that researchers and scientists from around the world can come together to find a solution. “We need all the brainpower we have to connect and work together to find a substitute to plastic that is not toxic and doesn’t last [in the environment] as long as plastic does,” she says.
From 2007 to 2016, the U.S. Food and Drug Administration flagged nearly 800 over-the-counter dietary supplements as tainted with potentially harmful pharmaceutical drugs, a study shows. Fewer than half of those products were recalled by their makers, scientists found.
Researchers analyzed the FDA’s public database of tainted supplements, identifying both the type of contaminating ingredients they contained and how the products were marketed. Most of these supplements, which are allowed to contain only dietary ingredients, included drugs such as steroids, the active ingredient in Viagra and a weight loss drug banned from the U.S. market eight years ago. The products had been marketed primarily for sexual enhancement, weight loss or muscle building, scientists report online October 12 in JAMA Network Open.
More than half of American adults have reported taking dietary supplements, such as vitamins, minerals and other specialty products. More than 85,000 supplements are estimated to be available in the United States, and the FDA says it cannot test all of them. No No’s These pharmaceutical ingredients are not permitted in dietary supplements, but were found to be contaminating supplements.
Sildenafil What it is: A medication that dilates blood vessels in the penis, and is the active ingredient in Viagra Health issue: Can lower blood pressure to levels that are unsafe for people taking medications for diabetes, high blood pressure or high cholesterol Supplement type: Sexual enhancement Sibutramine What it is: An appetite suppressant removed from the U.S. market in 2010 Health issue: Increased risk of heart attack or stroke Supplement type: Weight loss Phenolphthalein What it is: A laxative removed from the U.S. market in 1999 Health issue: Potential carcinogen Supplement type: Weight loss Anabolic steroids What they are: Chemicals related to the male sex hormone testosterone Health issue: Associated with liver injury, kidney damage, heart attack and stroke Supplement type: Muscle building Aromatase inhibitors What they are: A class of drugs that lower estrogen levels, and are used to treat breast cancer Health issue: Associated with decreased bone growth, infertility, liver dysfunction Supplement type: Muscle building These supplements aren’t subject to the same regulations, testing and approval process that are required for pharmaceutical drugs. But if the FDA identifies tainted supplements after they’re on the market, the agency can issue public warnings or suggest the company voluntarily remove the product.
Whether that approach is effective raises questions, though, says general internist Pieter Cohen of Cambridge Health Alliance in Cambridge, Mass., who was not involved in the new work. Voluntary recalls don’t necessarily mean a product is completely removed from shelves or that consumers become aware and stop using a product, Cohen’s research has found.
And only 360 of the 776 supplements flagged as tainted from 2007 to 2016 were recalled, the study found. “What really jumped out at me,” Cohen says, is that “when the FDA detects drugs in supplements, more than half the time the product isn’t even recalled.”
Supplement use does carry health risks. A 2015 study estimated that 23,000 emergency room visits each year are due to health problems related to dietary supplements. Of those, about 2,100 patients are hospitalized annually, commonly for symptoms related to heart trouble. In 2013, 20 percent of drug-induced liver injury cases recorded in the Drug-Induced Liver Injury Network registry were caused by dietary supplements. That’s up from 7 percent in 2004. Liver damage can be fatal or require a liver transplant. A 2013 report by the U.S. Centers for Disease Control and Prevention on 29 cases of liver injury found that 24 of those patients reported using a dietary supplement for weight loss.
“The law allows companies to advertise supplements as if they’re good for your health, even if there’s no evidence in humans that that’s the case,” Cohen says. He began studying dietary supplements after noting that his patients developed health problems, including panic attacks, chest pain and kidney failure, related to weight-loss supplements. One patient was suspended from his job when his urine tested positive for amphetamine; a chemical derivative of the drug was found in the weight-loss pills that he was taking.
Cohen’s recommendation? Avoid supplements “that promise you anything.”
Animated characters can learn from online tutorials, too.
A new computer program teaches virtual avatars new skills, such as dances, acrobatic stunts and martial art moves, from YouTube videos. This kind of system, described in the November ACM Transactions on Graphics, could render more physically coordinated characters for movies and video games, or serve as a virtual training ground for robots.
“I was really impressed” by the program, says Daniel Holden, a machine-learning researcher at Ubisoft La Forge in Montreal not involved in the work. Rendering accurate, natural-looking movements based on everyday video clips “has always been a goal for researchers in this field.” Animated characters typically have learned full-body motions by studying motion capture data, collected by a camera that tracks special markers attached to actors’ bodies. But this technique requires special equipment and often works only indoors.
The new program leverages a type of computer code known as an artificial neural network, which roughly mimics how the human brain processes information. Trained on about 100,000 images of people in various poses, the program first estimates an actor’s pose in each frame of a video clip. Then, it teaches a virtual avatar to re-create the actor’s motion using reinforcement learning, giving the character a virtual “reward” when it matches the video actor’s pose in a frame.
Computer scientist Jason Peng and colleagues at the University of California, Berkeley, fed YouTube videos into the system to teach characters to do somersaults, backflips, vaulting and other stunts. Even characters such as animated Atlas robots with bodies drastically different from those of their human video teachers mastered these motions (SN: 12/13/14, p. 16). Characters could also perform under conditions not seen in the training video, like cartwheeling while being pelted with blocks or moving across terrain riddled with holes. The work, also reported October 8 at arXiv.org, is a step “toward making motion capture easier, cheaper and more accessible,” Holden says. Videos could be used to render virtual versions of outdoor activities, since motion capture is difficult to do outdoors, or to create lifelike avatars of large animals that would be difficult to stick with motion capture markers.
This kind of program may also someday be used to teach robots new skills, Peng says. An animated version of a robot could master skills in a virtual environment before that learned computer code powered a machine in the physical world.
These animated characters still struggle with nimble dance steps, such as the “Gangnam Style” jig, and learn from short clips featuring only a single person. David Jacobs, a computer scientist at the University of Maryland in College Park not involved in the work, looks forward to future virtual avatars that can reenact longer, more complex actions, such as pairs of people dancing or soccer teams playing a game.
“That’s probably a much harder problem, because [each] person’s not as clearly visible, but it would be really cool,” Jacobs says. “This is only the beginning.”
A proton’s mass is more than just the sum of its parts. And now scientists know just what accounts for the subatomic particle’s heft.
Protons are made up of even smaller particles called quarks, so you might expect that simply adding up the quarks’ masses should give you the proton’s mass. However, that sum is much too small to explain the proton’s bulk. And new, detailed calculations show that only 9 percent of the proton’s heft comes from the mass of constituent quarks. The rest of the proton’s mass comes from complicated effects occurring inside the particle, researchers report in the Nov. 23 Physical Review Letters.
Quarks get their masses from a process connected to the Higgs boson, an elementary particle first detected in 2012 (SN: 7/28/12, p. 5). But “the quark masses are tiny,” says study coauthor and theoretical physicist Keh-Fei Liu of the University of Kentucky in Lexington. So, for protons, the Higgs explanation falls short.
Instead, most of the proton’s 938 million electron volts of mass is due to complexities of quantum chromodynamics, or QCD, the theory which accounts for the churning of particles within the proton. Making calculations with QCD is extremely difficult, so to study the proton’s properties theoretically, scientists rely on a technique called lattice QCD, in which space and time are broken up into a grid, upon which the quarks reside. Using this technique, physicists had previously calculated the proton’s mass (SN: 12/20/08, p. 13). But scientists hadn’t divvied up where that mass comes from until now, says theoretical physicist André Walker-Loud of Lawrence Berkeley National Laboratory in California. “It’s exciting because it’s a sign that … we’ve really hit this new era” in which lattice QCD can be used to better understand nuclear physics.
In addition to the 9 percent of the proton’s mass that comes from quarks’ heft, 32 percent comes from the energy of the quarks zipping around inside the proton, Liu and colleagues found. (That’s because energy and mass are two sides of the same coin, thanks to Einstein’s famous equation, E=mc2.) Other occupants of the proton, massless particles called gluons that help hold quarks together, contribute another 36 percent via their energy.
The remaining 23 percent arises due to quantum effects that occur when quarks and gluons interact in complicated ways within the proton. Those interactions cause QCD to flout a principle called scale invariance. In scale invariant theories, stretching or shrinking space and time makes no difference to the theories’ results. Massive particles provide the theory with a scale, so when QCD defies scale invariance, protons also gain mass.
The results of the study aren’t surprising, says theoretical physicist Andreas Kronfeld of Fermilab in Batavia, Ill. Scientists have long suspected that the proton’s mass was made up in this way. But, he says, “this kind of calculation replaces a belief with scientific knowledge.”
Off the Pacific coast of Costa Rica sits a deep-sea chimera of an ecosystem. Jacó Scar is a methane seep, where the gas escapes from sediment into the seawater, but the seep isn’t cold like the others found before it. Instead, geochemical activity gives the Scar lukewarm water that enables organisms from both traditionally colder seeps and scalding hot hydrothermal vents to call it home.
One resident of the Scar is a newly identified species of small, purplish fish called an eelpout, described for the first time on January 19 in Zootaxa. This fish is the first vertebrate species found at the Scar and could help scientists understand how the unique ecosystem developed. Jacó Scar was discovered during exploration of a known field of methane seeps off the Costa Rican coast and named for the nearby town of Jacó. It is “a really diverse place” with many different organisms living in various microhabitats, says Lisa Levin, a marine ecologist at Scripps Institution of Oceanography in La Jolla, Calif.
Levin was on one of the first expeditions to the Scar but wasn’t involved in the new study. She recalls the team finding and collecting one of the fish during this early excursion, but the researchers didn’t recognize it as a new species.
Several more specimens were snagged during later submersible dives. Charlotte Seid, an invertebrate biologist at Scripps who is working on a checklist of organisms found at the Costa Rican seeps, brought the fishy finds to ichthyologist Ben Frable, also of Scripps, for formal identification.
Frable says he knew the fish was an eelpout. They look exactly as one would expect based on their name: like frowning eels, though they aren’t true eels. But he was having trouble determining what type. Eelpouts are a diverse family of fish comprised of nearly 300 species that can be found all over the world at various ocean depths.
Because the physical differences between species can be subtle, they are “kind of a tricky group” to identify, Frable says. “I just was not really getting anywhere.” So the team turned to eelpout expert Peter Rask Møller of the Natural History Museum of Denmark in Copenhagen, sending him X-rays, pictures and eventually one of the fish specimens.
Møller narrowed the enigmatic eelpout to the genus Pyrolycus, meaning “fire wolf.” Turns out, the tool, called a dichotomous key, that Frable had been using to identify the specimens was outdated, made before Pyrolycus was described in 2002. “I did not know that genus existed,” Frable says.
Because the other two known Pyrolycus species live far away in the western Pacific and have different physical features, the team dubbed the mystery fish P. jaco — a new species.
The first eelpouts most likely evolved in cold waters, Frable says, but many have since made their home in the scalding waters of hydrothermal vents. Of the 24 known fish species that live only at hydrothermal vents, “13 of them are eelpouts,” Frable says. The new finding raises questions about how the known Pyrolycus species came to live so far apart. It may have to do with the fact that methane seeps are more common than previously thought on the ocean floor, and if some are lukewarm like Jacó Scar, the new species could have used them as refuges while moving east.
And by comparing P. jaco to its vent-living relatives, researchers may be able to figure out how it adapted to live in the tepid waters of the Scar — which may provide clues to how other species living there did too.
The eelpout is part of a medley of other species that form Jacó Scar’s composite ecosystem, along with, for example, clams typically found at cold seeps and bacteria found at hydrothermal vents. Jacó Scar is a “mixing bowl” of species found in other parts of the world, Seid says. Figuring out how this eclectic bunch interacts “is part of the fun.”
Editor’s note: On April 10, the Event Horizon Telescope collaboration released a picture of the supermassive black hole at the center of galaxy M87. Read the full story here.
We’re about to see the first close-up of a black hole.
The Event Horizon Telescope, a network of eight radio observatories spanning the globe, has set its sights on a pair of behemoths: Sagittarius A*, the supermassive black hole at the Milky Way’s center, and an even more massive black hole 53.5 million light-years away in galaxy M87 (SN Online: 4/5/17). In April 2017, the observatories teamed up to observe the black holes’ event horizons, the boundary beyond which gravity is so extreme that even light can’t escape (SN: 5/31/14, p. 16). After almost two years of rendering the data, scientists are gearing up to release the first images in April.
Here’s what scientists hope those images can tell us.
What does a black hole really look like? Black holes live up to their names: The great gravitational beasts emit no light in any part of the electromagnetic spectrum, so they themselves don’t look like much.
But astronomers know the objects are there because of a black hole’s entourage. As a black hole’s gravity pulls in gas and dust, matter settles into an orbiting disk, with atoms jostling one another at extreme speeds. All that activity heats the matter white-hot, so it emits X-rays and other high-energy radiation. The most voraciously feeding black holes in the universe have disks that outshine all the stars in their galaxies (SN Online: 3/16/18). The EHT’s image of the Milky Way’s Sagittarius A, also called SgrA, is expected to capture the black hole’s shadow on its accompanying disk of bright material. Computer simulations and the laws of gravitational physics give astronomers a pretty good idea of what to expect. Because of the intense gravity near a black hole, the disk’s light will be warped around the event horizon in a ring, so even the material behind the black hole will be visible. And the image will probably look asymmetrical: Gravity will bend light from the inner part of the disk toward Earth more strongly than the outer part, making one side appear brighter in a lopsided ring.
Does general relativity hold up close to a black hole? The exact shape of the ring may help break one of the most frustrating stalemates in theoretical physics.
The twin pillars of physics are Einstein’s theory of general relativity, which governs massive and gravitationally rich things like black holes, and quantum mechanics, which governs the weird world of subatomic particles. Each works precisely in its own domain. But they can’t work together.
“General relativity as it is and quantum mechanics as it is are incompatible with each other,” says physicist Lia Medeiros of the University of Arizona in Tucson. “Rock, hard place. Something has to give.” If general relativity buckles at a black hole’s boundary, it may point the way forward for theorists.
Since black holes are the most extreme gravitational environments in the universe, they’re the best environment to crash test theories of gravity. It’s like throwing theories at a wall and seeing whether — or how — they break. If general relativity does hold up, scientists expect that the black hole will have a particular shadow and thus ring shape; if Einstein’s theory of gravity breaks down, a different shadow.
Medeiros and her colleagues ran computer simulations of 12,000 different black hole shadows that could differ from Einstein’s predictions. “If it’s anything different, [alternative theories of gravity] just got a Christmas present,” says Medeiros, who presented the simulation results in January in Seattle at the American Astronomical Society meeting. Even slight deviations from general relativity could create different enough shadows for EHT to probe, allowing astronomers to quantify how different what they see is from what they expect. Do stellar corpses called pulsars surround the Milky Way’s black hole? Another way to test general relativity around black holes is to watch how stars careen around them. As light flees the extreme gravity in a black hole’s vicinity, its waves get stretched out, making the light appear redder. This process, called gravitational redshift, is predicted by general relativity and was observed near SgrA* last year (SN: 8/18/18, p. 12). So far, so good for Einstein.
An even better way to do the same test would be with a pulsar, a rapidly spinning stellar corpse that sweeps the sky with a beam of radiation in a regular cadence that makes it appear to pulse (SN: 3/17/18, p. 4). Gravitational redshift would mess up the pulsars’ metronomic pacing, potentially giving a far more precise test of general relativity.
“The dream for most people who are trying to do SgrA* science, in general, is to try to find a pulsar or pulsars orbiting” the black hole, says astronomer Scott Ransom of the National Radio Astronomy Observatory in Charlottesville, Va. “There are a lot of quite interesting and quite deep tests of [general relativity] that pulsars can provide, that EHT [alone] won’t.”
Despite careful searches, no pulsars have been found near enough to SgrA* yet, partly because gas and dust in the galactic center scatters their beams and makes them difficult to spot. But EHT is taking the best look yet at that center in radio wavelengths, so Ransom and colleagues hope it might be able to spot some.
“It’s a fishing expedition, and the chances of catching a whopper are really small,” Ransom says. “But if we do, it’s totally worth it.” How do some black holes make jets? Some black holes are ravenous gluttons, pulling in massive amounts of gas and dust, while others are picky eaters. No one knows why. SgrA* seems to be one of the fussy ones, with a surprisingly dim accretion disk despite its 4 million solar mass heft. EHT’s other target, the black hole in galaxy M87, is a voracious eater, weighing in at between about 3.5 billion and 7.22 billion solar masses. And it doesn’t just amass a bright accretion disk. It also launches a bright, fast jet of charged subatomic particles that stretches for about 5,000 light-years.
“It’s a little bit counterintuitive to think a black hole spills out something,” says astrophysicist Thomas Krichbaum of the Max Planck Institute for Radio Astronomy in Bonn, Germany. “Usually people think it only swallows something.”
Many other black holes produce jets that are longer and wider than entire galaxies and can extend billions of light-years from the black hole. “The natural question arises: What is so powerful to launch these jets to such large distances?” Krichbaum says. “Now with the EHT, we can for the first time trace what is happening.”
EHT’s measurements of M87’s black hole will help estimate the strength of its magnetic field, which astronomers think is related to the jet-launching mechanism. And measurements of the jet’s properties when it’s close to the black hole will help determine where the jet originates — in the innermost part of the accretion disk, farther out in the disk or from the black hole itself. Those observations might also reveal whether the jet is launched by something about the black hole itself or by the fast-flowing material in the accretion disk.
Since jets can carry material out of the galactic center and into the regions between galaxies, they can influence how galaxies grow and evolve, and even where stars and planets form (SN: 7/21/18, p. 16).
“It is important to understanding the evolution of galaxies, from the early formation of black holes to the formation of stars and later to the formation of life,” Krichbaum says. “This is a big, big story. We are just contributing with our studies of black hole jets a little bit to the bigger puzzle.”
Editor’s note: This story was updated April 1, 2019, to correct the mass of M87’s black hole; the entire galaxy’s mass is 2.4 trillion solar masses, but the black hole itself weighs in at several billion solar masses. In addition, the black hole simulation is an example of one that uphold’s Einstein’s theory of general relativity, not one that deviates from it.
When you’re stressed and anxious, you might feel your heart race. Is your heart racing because you’re afraid? Or does your speeding heart itself contribute to your anxiety? Both could be true, a new study in mice suggests.
By artificially increasing the heart rates of mice, scientists were able to increase anxiety-like behaviors — ones that the team then calmed by turning off a particular part of the brain. The study, published in the March 9 Nature, shows that in high-risk contexts, a racing heart could go to your head and increase anxiety. The findings could offer a new angle for studying and, potentially, treating anxiety disorders. The idea that body sensations might contribute to emotions in the brain goes back at least to one of the founders of psychology, William James, says Karl Deisseroth, a neuroscientist at Stanford University. In James’ 1890 book The Principles of Psychology, he put forward the idea that emotion follows what the body experiences. “We feel sorry because we cry, angry because we strike, afraid because we tremble,” James wrote.
The brain certainly can sense internal body signals, a phenomenon called interoception. But whether those sensations — like a racing heart — can contribute to emotion is difficult to prove, says Anna Beyeler, a neuroscientist at the French National Institute of Health and Medical Research in Bordeaux. She studies brain circuitry related to emotion and wrote a commentary on the new study but was not involved in the research. “I’m sure a lot of people have thought of doing these experiments, but no one really had the tools,” she says.
Deisseroth has spent his career developing those tools. He is one of the scientists who developed optogenetics — a technique that uses viruses to modify the genes of specific cells to respond to bursts of light (SN: 6/18/21; SN: 1/15/10). Scientists can use the flip of a light switch to activate or suppress the activity of those cells. In the new study, Deisseroth and his colleagues used a light attached to a tiny vest over a mouse’s genetically engineered heart to change the animal’s heart rate. When the light was off, a mouse’s heart pumped at about 600 beats per minute. But when the team turned on a light that flashed at 900 beats per minutes, the mouse’s heartbeat followed suit. “It’s a nice reasonable acceleration, [one a mouse] would encounter in a time of stress or fear,” Deisseroth explains.
When the mice felt their hearts racing, they showed anxiety-like behavior. In risky scenarios — like open areas where a little mouse might be someone’s lunch — the rodents slunk along the walls and lurked in darker corners. When pressing a lever for water that could sometimes be coupled with a mild shock, mice with normal heart rates still pressed without hesitation. But mice with racing hearts decided they’d rather go thirsty.
“Everybody was expecting that, but it’s the first time that it has been clearly demonstrated,” Beyeler says. The researchers also scanned the animals’ brains to find areas that might be processing the increased heart rate. One of the biggest signals, Deisseroth says, came from the posterior insula (SN: 4/25/16). “The insula was interesting because it’s highly connected with interoceptive circuitry,” he explains. “When we saw that signal, [our] interest was definitely piqued.”
Using more optogenetics, the team reduced activity in the posterior insula, which decreased the mice’s anxiety-like behaviors. The animals’ hearts still raced, but they behaved more normally, spending some time in open areas of mazes and pressing levers for water without fear. A lot of people are very excited about the work, says Wen Chen, the branch chief of basic medicine research for complementary and integrative health at the National Center for Complementary and Integrative Health in Bethesda, Md. “No matter what kind of meetings I go into, in the last two days, everybody brought up this paper,” says Chen, who wasn’t involved in the research.
The next step, Deisseroth says, is to look at other parts of the body that might affect anxiety. “We can feel it in our gut sometimes, or we can feel it in our neck or shoulders,” he says. Using optogenetics to tense a mouse’s muscles, or give them tummy butterflies, might reveal other pathways that produce fearful or anxiety-like behaviors.
Understanding the link between heart and head could eventually factor into how doctors treat panic and anxiety, Beyeler says. But the path between the lab and the clinic, she notes, is much more convoluted than that of the heart to the head.
An experimental treatment for endometriosis, a painful gynecological disease that affects some 190 million people worldwide, may one day offer new hope for easing symptoms.
Monthly antibody injections reversed telltale signs of endometriosis in monkeys, researchers report February 22 in Science Translational Medicine. The antibody targets IL-8, a molecule that whips up inflammation inside the scattered, sometimes bleeding lesions that mark the disease. After neutralizing IL-8, those hallmark lesions shrink, the team found.
The new treatment is “pretty potent,” says Philippa Saunders, a reproductive scientist at the University of Edinburgh who was not involved with work. The study’s authors haven’t reported a cure, she points out, but their antibody does seem to have an impact. “I think it’s really very promising,” she says.
Many scientists think endometriosis occurs when bits of the uterine lining — the endometrium — slough off during menstruation. Instead of exiting via the vagina, they voyage in the other direction: up through the fallopian tubes. Those bits of tissue then trespass through the body, sprouting lesions where they land. They’ll glom onto the ovaries, fallopian tubes, bladder and other spots outside of the uterus and take on a life of their own, Saunders says. The lesions can grow nerve cells, form tough nubs of tissue and even bleed during menstrual cycles. They can also kick off chronic bouts of pelvic pain. If you have endometriosis, you can experience “pain when you urinate, pain when you defecate, pain when you have sex, pain when you move around,” Saunders says. People with the disease can also struggle with infertility and depression, she adds. “It’s really nasty.” Once diagnosed, patients face a dearth of treatment options — there’s no cure, only therapies to alleviate symptoms. Surgery to remove lesions can help, but symptoms often come back.
The disease affects at least 10 percent of girls, women and transgender men in their reproductive years, Saunders says. And people typically suffer for years — about eight on average — before a diagnosis. “Doctors consider menstrual pelvic pain a very common thing,” says Ayako Nishimoto-Kakiuchi, a pharmacologist at Chugai Pharmaceutical Co. Ltd. in Tokyo. Endometriosis “is underestimated in the clinic,” she says. “I strongly believe that this disease has been understudied.”
Hormonal drugs that stop ovulation and menstruation can also offer relief, says Serdar Bulun, a reproductive endocrinologist at Northwestern University Feinberg School of Medicine in Chicago not involved with the new study. But those drugs come with side effects and aren’t ideal for people trying to become pregnant. “I see these patients day in and day out,” he says. “I see how much they suffer, and I feel like we are not doing enough.”
Nishimoto-Kakiuchi’s team engineered an antibody that grabs onto the inflammatory factor IL-8, a protein that scientists have previously fingered as one potential culprit in the disease. The antibody acts like a garbage collector, Nishimoto-Kakiuchi says. It grabs IL-8, delivers it to the cell’s waste disposal machinery, and then heads out to snare more IL-8.
The team tested the antibody in cynomolgus monkeys that were surgically modified to have the disease. (Endometriosis rarely shows up spontaneously in these monkeys, the scientists discovered previously after screening more than 600 females.) The team treated 11 monkeys with the antibody injection once a month for six months. In these animals, lesions shriveled and the adhesive tissue that glues them to the body thinned out, too. Before this study, Nishimoto-Kakiuchi says, the team didn’t think such signs of endometriosis were reversible. Her company has now started a Phase I clinical trial to test the safety of therapy in humans. The treatment is one of several endometriosis therapies scientists are testing (SN: 7/19/19) . Other trials will test new hormonal drugs, robot-assisted surgery and behavioral interventions.
Doctors need new options to help people with the disease, Saunders says. “There’s a huge unmet clinical need.”
SpaceX’s rapidly growing fleet of Starlink internet satellites now make up half of all active satellites in Earth orbit.
On February 27, the aerospace company launched 21 new satellites to join its broadband internet Starlink fleet. That brought the total number of active Starlink satellites to 3,660, or about 50 percent of the nearly 7,300 active satellites in orbit, according to analysis by astronomer Jonathan McDowell using data from SpaceX and the U.S. Space Force. “These big low-orbit internet constellations have come from nowhere in 2019, to dominating the space environment in 2023,” says McDowell, of the Harvard-Smithsonian Center for Astrophysics in Cambridge, Mass. “It really is a massive shift and a massive industrialization of low orbit.”
SpaceX has been launching Starlink satellites since 2019 with the goal of bringing broadband internet to remote parts of the globe. And for just as long, astronomers have been warning that the bright satellites could mess up their view of the cosmos by leaving streaks on telescope images as they glide past (SN: 3/12/20).
Even the Hubble Space Telescope, which orbits more than 500 kilometers above the Earth’s surface, is vulnerable to these satellite streaks, as well as those from other satellite constellations. From 2002 to 2021, the percentage of Hubble images affected by light from low-orbit satellites increased by about 50 percent, astronomer Sandor Kruk of the Max-Planck Institute for Extraterrestrial Physics in Garching, Germany, and colleagues report March 2 in Nature Astronomy.
The number of images partially blocked by satellites is still small, the team found, rising from nearly 3 percent of images taken between 2002 and 2005 to just over 4 percent between 2018 and 2021 for one of Hubble’s cameras. But there are already thousands more Starlink satellites now than there were in 2021.
“The fraction of [Hubble] images crossed by satellites is currently small with a negligible impact on science,” Kruk and colleagues write. “However, the number of satellites and space debris will only increase in the future.” The team predicts that by the 2030s, the probability of a satellite crossing Hubble’s field of view any time it takes an image will be between 20 and 50 percent. The sudden jump in Starlink satellites also poses a problem for space traffic, says astronomer Samantha Lawler of the University of Regina in Canada. Starlink satellites all orbit at a similar distance from Earth, just above 500 kilometers.
“Starlink is the densest patch of space that has ever existed,” Lawler says. The satellites are constantly navigating out of each other’s way to avoid collisions (SN: 2/12/09). And it’s a popular orbital altitude — Hubble is there, and so is the International Space Station and the Chinese space station. “If there is some kind of collision [between Starlinks], some kind of mishap, it could immediately affect human lives,” Lawler says.
SpaceX launches Starlink satellites roughly once per week — it launched 51 more on March 3. And they’re not the only company launching constellations of internet satellites. By the 2030s, there could be 100,000 satellites crowding low Earth orbit.
So far, there are no international regulations to curb the number of satellites a private company can launch or to limit which orbits they can occupy.
“The speed of commercial development is much faster than the speed of regulation change,” McDowell says. “There needs to be an overhaul of space traffic management and space regulation generally to cope with these massive commercial projects.”
